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CAMZYOS (mavacamten) mechanism of action

CAMZYOS is the first and only licensed selective, allosteric and reversible cardiac myosin inhibitor for symptomatic NYHA class II and III
obstructive HCM.1

CAMZYOS is the only licensed non-invasive oral therapy that targets the underlying pathophysiology of obstructive HCM by reducing excess formation of myosin-actin cross bridging.1–3

CAMZYOS modulates the number of myosin heads that can enter power-generating states, thus reducing the probability of force-producing systolic and residual diastolic cross-bridge formation.1

 

Inside the obstructive HCM sarcomere with and without CAMZYOS2,3

Sarcomere in obstructive HCM
(excess myosin-actin cross bridging)

Sarcomere in obstructive HCM

Sarcomere in obstructive HCM with CAMZYOS
(reduced myosin-actin cross bridging)

Sarcomere in obstructive HCM with CAMZYOS

Adapted from Desai MY et al. 2022.3

Cardiac myosin inhibition with CAMZYOS:1

Normalises contractility

Normalises contractility

Reduces dynamic LVOT obstruction

Reduces dynamic LVOT obstruction

Improves cardiac filling pressures

Improves cardiac filling pressures

Discover how CAMZYOS works

Camzyos MOA video
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HCM, hypertrophic cardiomyopathy; LVOT, left ventricular outflow tract; NYHA, New York Heart Association.

References
  1. CAMZYOS (mavacamten) Summary of Product Characteristics. 
  2. Olivotto I et al. Lancet. 2020;396(10253):759–769. 
  3. Desai MY et al. J Am Coll Cardiol. 2022;80(2):95–108.