Identifying patients for CAMZYOS (mavacamten)

While not all patients with obstructive HCM have symptoms, those that have symptomatic obstructive HCM may display a variety of signs and symptoms that may facilitate recognition of the condition in the general practice and prompt referral to a cardiologist to confirm diagnosis.¹

Potential signs and symptoms in patients with obstructive HCM:¹

Fatigue/Tiredness
Breathlessness
Orthopnoea
Dizziness
Angina
Palpitations
Arrythmias
Syncope
Pulmonary congestion
Excessive sweating

Potential complications of obstructive HCM:^1–4

Heart failure
Cardiac arrest
Endocarditis
Stroke
Atrial fibrillation

Potential impact of obstructive HCM on patient’s lives:^1,5

Limits capacity to be physically active
Limitation on daily tasks
Emotional toll
Anxiety and/or depression
Affects ability to work
Disrupted family and social life
Poor sleep quality

Challenges when diagnosing obstructive HCM

HCM, hypertrophic cardiomyopathy.

References

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3500-GB-2500038 | March 2025