This site is only for patients in the United Kingdom who have been prescribed CAMZYOS®▼ (mavacamten)

This site is only for patients in the United Kingdom who have been prescribed CAMZYOS®▼ (mavacamten)

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CYP2C19 testing

Before you start taking CAMZYOS, your healthcare team will need to work out your starting dose. They will use a type of test called a CYP2C19 test to do this. It is important to speak to your healthcare team if you have any questions about CYP2C19 testing or CAMZYOS.

What is the CYP2C19 test?

The CYP2C19 test is a pharmacogenetic test that looks at specific genes to see how fast one of your enzymes (CYP2C19) breaks down (metabolises) CAMZYOS and other medicines. 

CYP2C19 test icon

For the CYP2C19 test, your healthcare team will take a sample of your blood to send to a testing facility

The CYP2C19 test is different from genetic tests, which look at many different genes to see what is causing a disease.

Understanding the purpose for doing CYP2C19 testing

The CYP2C19 test allows your doctor to see how active your CYP2C19 enzyme is. This activity is known as your ‘metaboliser status’, which can range from ‘slow metaboliser’ to ‘ultra-rapid metaboliser’ (see the diagram below). These results will help your doctor decide on the most appropriate CAMZYOS dose for you.

Interpreting CYP2C19 test results
slow metaboliser diagram

Slow metaboliser

This means that you break down certain medicines slowly. This may affect the dose of CAMZYOS you are given and what other medicines you can take at the same time.

Intermediate, normal, rapid or ultra-rapid metaboliser diagram

Intermediate, normal, rapid, or ultra-rapid metaboliser

This means that you break down certain medicines quickly or at a normal pace. Your doctor may be able to increase your dose of CAMZYOS depending on how well you are doing on your current dose.

Your doctor will explain your results and what this means for your CAMZYOS treatment